- by Carla P LoureiroAcceptance and Commitment Therapy (ACT) has shown promise as a treatment for obsessive-compulsive disorder (OCD) in clinical trials; however, its cross-cultural applicability remains underexplored. This systematic review and meta-analysis assessed ACT's global efficacy across diverse cultural contexts. A comprehensive search of MEDLINE, Scopus, Web of Science, PsycINFO, Google Scholar, and ClinicalTrials.gov identified 468 records, of which nine randomized controlled trials (RCTs) met inclusion…
- by Gabriella Restifo-BernsteinGlutamatergic dysfunction in cortico-striato-thalamo-cortical (CSTC) circuits is a hypothesized cause of obsessive-compulsive disorder (OCD). Numerous proton magnetic resonance spectroscopy (¹H MRS) studies have examined this question, yet no systematic review has been conducted in unmedicated participants with OCD. We searched PubMed, Web of Science, and Embase for ¹H MRS studies examining glutamate (Glu) and the related metabolites glutamine (Gln) and γ-aminobutyric acid (GABA), which are…
- by Yihui ChengCONCLUSIONS: This comprehensive review of up-to-date neurobiological studies of individuals with BDD reveals differences in brain structure and functionality compared with control participants. The proposed neurocircuitry model expands on the previous understanding of BDD neurobiology and elucidates the interconnection between the visual processing, temporal-limbic, and frontostriatal networks and their clinical implications. This review provides theoretical support for future neuromodulation…
- by Lenka OttingerováChairwork refers to a set of experiential psychotherapeutic interventions in which the physical positioning of the chairs facilitates internal and interpersonal dialogue. This study is an attempt to rectify the lack of a systematic review of the research on the effectiveness of Chairwork by offering a systematic review of randomized controlled trials (RCTs) that assess the effectiveness of Chairwork-based interventions used in various psychotherapeutic approaches for the treatment of…
- by Emily J FawcettObsessive-compulsive disorder (OCD) is a heterogeneous condition often characterized in relation to major symptom dimensions, including contamination, symmetry/exactness, religious, aggressive, sexual, hoarding/saving, somatic, and miscellaneous. Aggressive obsessions, defined as intrusive thoughts of (unintentionally or intentionally) harming oneself or others, are experienced as distressing, commonly misdiagnosed by healthcare providers, and highly stigmatized. The aims of the current study…
- by Ayush PandeyCONCLUSION: Risperidone plays a significant role in reduction of Y-BOCS score in OCD patients, whereas memantine does not show a significant effect in reducing the Y-BOCS score in OCD patients.
- by Margherita ZenoniCONCLUSIONS: Trauma seems to significantly amplify OCD symptom severity and influence symptom presentation. Trauma-informed clinical assessment and tailored interventions should be integral to OCD treatment.
- by Claire TileyCONCLUSIONS: This review indicates higher ASD traits and diagnosis in children and adolescents with OCD compared with the general population. Limited data and methodological constraints in trials limit generalisability, warranting further research.
- by Joshua W BryanCONCLUSION: Overall, current evidence does not support the routine use of memantine for OCD. However, it does highlight specific methodological considerations and priorities for future rigorous investigation. Future randomised controlled trials with larger samples, longer follow-ups, and standardised dosing protocols are needed to clearly determine memantine’s role in OCD management.
- by Mohammad KhosraviObsessive-Compulsive Disorder (OCD) is a chronic psychiatric disorder characterized by intrusive thoughts and repetitive behaviors, leading to significant distress and functional impairment. First-line treatments include selective serotonin reuptake inhibitors and cognitive-behavioral therapy, particularly exposure and response prevention (ERP). However, a substantial proportion of patients exhibit limited or no response to these interventions. Repetitive transcranial magnetic stimulation (rTMS)…
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