- by Teodor-Georgian NuțăBackground and Objectives: Keratoconus (KC) is a progressive corneal ectasia with multifactorial etiology, increasingly studied for potential associations with psychiatric disorders. This systematic review aimed to evaluate recent evidence linking KC with depression and other psychiatric conditions, including psychotic disorders, personality disorders, attention deficit hyperactivity disorder (ADHD), Tourette syndrome (TS), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD)….
- by Mohamad W MidouObsessive-compulsive symptoms (OCS) and obsessive-compulsive disorder (OCD) can co-occur with schizophrenia spectrum disorders. There is limited research on electroconvulsive therapy (ECT) for this particular comorbidity. This systematic review assessed the efficacy of ECT for OCS/OCD in patients with schizophrenia spectrum disorders. A systematic literature search was conducted using multiple databases. Inclusion criteria for articles included those involving patients with both OCS/OCD and…
- by Maria Madalena Correia FigueiredoCONCLUSION: The conclusion drawn from this analysis is that rTMS constitutes an effective treatment for OCD, particularly when administered to specific targets and at specific frequencies. Nevertheless, the mean clinical impact is negligible. The findings indicate the necessity of optimised protocols and pragmatic maintenance strategies.
- by Shayan EghdamiObsessive-compulsive disorder (OCD) is a multifactorial condition, and interest in gut-brain interactions is increasing. We conducted a systematic two-step review, registered in PROSPERO (CRD420251083936). Step 1 mapped core OCD biology to gut-relevant pathways, including neuroimmune activation, epithelial barrier function, microbial metabolites, and stress circuitry, to clarify plausible mechanisms. Step 2 synthesized evidence from human and preclinical studies that measured or manipulated…
- by Armin ToghiCONCLUSIONS: Eye-tracking metrics could serve as transdiagnostic biomarkers for identifying inattention symptoms across normative and psychiatric conditions. Further research is needed to transition eye-tracking from a research tool to a clinically actionable biomarker for personalized assessment and intervention.
- by Naga Venkata Satish Babu BodapatiObsessive-compulsive disorder (OCD) and adolescent depression are debilitating conditions where standard treatments often yield suboptimal outcomes. Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique with established efficacy in adults with OCD, but its role in adolescent depression remains less defined. This systematic review aims to synthesize the current evidence on the efficacy, safety, and predictors of treatment response for TMS in adults with OCD and…
- by Katherine E KabotyanskiThe quest to develop and improve neuromodulatory therapies for treatment-resistant psychiatric disorders has been fueled by the discovery of intracranial neural biomarkers of symptom dimensions. These neural correlates shed light on the underlying neurophysiology of the disorder and may even be useful in guiding therapy delivery. This systematic review summarizes recent efforts in this field relating neural activity to behavior and symptomatology. For years, the majority of these neurobehavioral…
- by Martin Sellier SilvaCONCLUSIONS: Externally validated longitudinal studies on the predictive value of speech/language markers of youth-onset mental disorders are scarce, restricted to a few target disorders and do not allow for variations due to the developmental stage of the samples. Nonetheless, existing studies highlight the potential of applying Natural Language Processing methods to speech samples from both youth and parents for early identification.
- by Yoann BirlingThe objective of this systematic review is to assess the effectiveness and safety of Chinese Herbal Medicine (CHM) for anxiety disorders and obsessive-compulsive disorder (OCD). EMBase, PubMed, CINAHL, CNKI, Wanfang, CQVIP, clinicaltrials.gov and Chinese Clinical Trial Registry were searched from database inception to January 2025 using search terms defining "anxiety/OCD", "Chinese herbal medicine" and "randomized controlled trial". From a total of 9805 reports screened, 92 randomised-controlled…
- by Asila A Ferguson[This corrects the article DOI: 10.7759/cureus.37833.].
What People Say
The way to get started is to quit talking and begin doing.
Walt Disney
It is our choices, Harry, that show what we truly are, far more than our abilities.
J. K. Rowling
Don’t cry because it’s over, smile because it happened.
Dr. Seuss
Psychiatry Training UK 