- by Juhui DengCONCLUSION: Exercise may benefit OCD symptoms; however, randomized controlled trials showed no significant effect, and single-group findings should be interpreted as supportive evidence. For bipolar disorder, no significant effect was found for depressive symptoms, while a potential effect on manic symptoms cannot be excluded. Larger randomized controlled trials are needed. These findings provide preliminary evidence for exercise-based adjunctive interventions.
- by Dominika M KaraszewskaBACKGROUND: Deep brain stimulation (DBS) is effective in treating severe obsessive-compulsive disorder (OCD) and treatment-resistant depression (TRD). However, patient referrals for DBS remain lower than expected based on prevalence and eligibility. Understanding the factors behind this gap is crucial for improving DBS implementation. This study aimed to identify key barriers and facilitators influencing DBS use for OCD and TRD. Insights from this research may help policymakers and clinicians…
- by Catherine SowerbyCONCLUSIONS: Although many eligible studies evaluated MRI or EEG for diagnosis and/or treatment response for depressive disorders, most were small and cross-sectional. There was less existing evidence examining other neuroimaging techniques or focusing on other mental health disorders (PTSD, OCD, anxiety disorders, or SUD). Given these evidence gaps, it is likely premature to implement neuroimaging and neurophysiologic tests in clinical settings. To determine clinical utility, future research…
- by Leila MirzaeiObjective: This study systematically integrates and reviews the results of Iranian studies on the effectiveness of cognitive behavioral therapy (CBT) for emotional disorders. Method : To ensure a comprehensive review, relevant Iranian studies from 2001 to 2024 were identified from databases such as Google Scholar, Web of Science, Scopus, PubMed, SID, Noormags, and MagIran using keywords including CBT, emotional disorders, anxiety, depression, OCD, PTSD, and stress. Results: Based on the…
- by Michael IoannouIn severe cases of depression and obsessive-compulsive disorder (OCD), clomipramine is sometimes administered parenterally. This systematic review aimed to investigate whether parenteral clomipramine is superior to oral clomipramine or other treatments, primarily in terms of reducing depressive/OCD symptoms within two weeks (CRD420250654029). Medline, Embase, the Cochrane Library, and PsycInfo were searched for relevant publications. Randomized controlled trials (RCTs) without a high risk of…
- by Shiv PatilCONCLUSIONS: PET provides insight into the effects of DBS on the molecular activity of the brain, which may improve patient selection for surgery, prognostication, and long-term monitoring.
- by Anya C EnglishBackground: Decades of randomized controlled trials (RCTs) support cognitive behavioral therapy (CBT) for pediatric anxiety, but exclusion criteria may limit generalizability to routine settings. We examined common exclusion criteria in recent CBT RCTs for pediatric anxiety, trends in these criteria over time, and whether meeting RCT exclusion criteria affects outcomes in a naturalistic sample. Methods: We reviewed 81 RCTs from the past 25 years assessing CBT for pediatric anxiety or related…
- by Ruoyu MaCONCLUSIONS: This systematic review, meta-analysis, and case study suggest that circuit-based neuromodulation-particularly targeting the fronto-limbic circuit-may offer the most consistent benefit for treatment-refractory OCD. Larger, longer-term, and circuit-informed trials are needed to optimize individualized neuromodulation strategies.
- by Michelangelo Di LuzioBackground: It is well documented in the scientific literature that obsessive-compulsive disorder (OCD) and various eating disorders may present overlapping psychopathological traits. Exploring these aspects could help to identify underlying features that connect different diagnostic categories. However, evidence is lacking regarding certain less-studied eating disorders, such as avoidant/restrictive food intake disorder (ARFID). The aim of this review is to investigate the presence of…
- by Shivani M ReddyCONCLUSIONS: TMS probably improves clinical response in OCD and may improve symptom severity in GAD, OCD, and PTSD. Further research should determine optimal brain targets and TMS treatment parameters and assess the durability of outcomes at longer term follow-up times, to better support clinical decision making and coverage determinations.
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