- by Şenay KılınçelCONCLUSION: The findings supported the clinical relevance of assessing problematic internet use in child and adolescent psychiatric practice. Integrating routine screening into mental health evaluations may facilitate identify at-risk individuals earlier.
- by Ammar ShahtouObsessive-compulsive disorder (OCD) is a chronic neuropsychiatric condition. While selective serotonin reuptake inhibitors (SSRIs) are a standard treatment, many patients experience an inadequate response to monotherapy. For individuals with treatment-resistant OCD (TR-OCD), antipsychotic augmentation is a commonly utilized pharmacological strategy. This review aimed to systematically review the literature and conduct a frequentist network meta-analysis (NMA) to evaluate the comparative…
- by Santhosh G ThavarajasingamObsessive-compulsive disorder (OCD) is a chronic and debilitating condition, often resistant to conventional treatments. Deep brain stimulation (DBS) emerges as a promising intervention, but its efficacy varies among patients, underscoring the need to understand the predictive factors influencing its outcomes. To evaluate and compare disease and patient characteristics in their ability to predict response to DBS in OCD patients. All major databases were searched for original studies. This study…
- by Matthew E SloanPsychiatric disorders are among the leading contributors to the global burden of disease. Impaired emotion regulation has been hypothesized to be a transdiagnostic feature of psychiatric disorders, but this has not been proven across all classes of psychopathology. We sought to systematically review and meta-analyze emotion regulation impairment across major psychiatric disorders to determine if impairment is truly transdiagnostic. Selected studies compared healthy controls and individuals with…
- by Vassilis MartiadisBackground/Objectives: Although obsessive-compulsive disorder (OCD) is clinically heterogeneous, it is unclear whether specific metacognitive belief domains are differentially associated with particular symptom dimensions in adults with confirmed OCD. This systematic review synthesised the available clinical evidence and explored its implications for dimension-informed case formulation and treatment planning. Methods: In March 2026, PubMed/MEDLINE, Scopus, Cochrane CENTRAL and Google Scholar…
- by William HintonCONCLUSIONS: The limited number of studies and high heterogeneity in the population-level cohort limit any firm conclusions. However, the findings indicate that OCSs may increase the risk of developing psychosis in the register-based cohorts, but not in CHR cohorts. The discrepancy may reflect shared underlying vulnerabilities present in both OCSs and psychosis that are obscured by samples enriched for psychosis risk.
- by Lucy SnellInteroception, defined as the perception of internal bodily states, has emerged as a key mechanism implicated in the development and maintenance of anxiety-related disorders. This systematic review synthesises evidence on the relationship between interoception and anxiety in adult clinical populations, with a specific focus on how distinct interoceptive dimensions (i.e., accuracy, attention, and beliefs) relate to different anxiety, stress and obsessive-compulsive presentations. A systematic…
- by Juhui DengCONCLUSION: Exercise may benefit OCD symptoms; however, randomized controlled trials showed no significant effect, and single-group findings should be interpreted as supportive evidence. For bipolar disorder, no significant effect was found for depressive symptoms, while a potential effect on manic symptoms cannot be excluded. Larger randomized controlled trials are needed. These findings provide preliminary evidence for exercise-based adjunctive interventions.
- by Dominika M KaraszewskaBACKGROUND: Deep brain stimulation (DBS) is effective in treating severe obsessive-compulsive disorder (OCD) and treatment-resistant depression (TRD). However, patient referrals for DBS remain lower than expected based on prevalence and eligibility. Understanding the factors behind this gap is crucial for improving DBS implementation. This study aimed to identify key barriers and facilitators influencing DBS use for OCD and TRD. Insights from this research may help policymakers and clinicians…
- by Catherine SowerbyCONCLUSIONS: Although many eligible studies evaluated MRI or EEG for diagnosis and/or treatment response for depressive disorders, most were small and cross-sectional. There was less existing evidence examining other neuroimaging techniques or focusing on other mental health disorders (PTSD, OCD, anxiety disorders, or SUD). Given these evidence gaps, it is likely premature to implement neuroimaging and neurophysiologic tests in clinical settings. To determine clinical utility, future research…
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