• Deep Brain Stimulation for Psychiatric Disorders: A Systematic Review of Molecular Imaging with PET
  April 1, 2026 by Shiv Patil
  CONCLUSION: PET provides insight into the effects of DBS on the molecular activity of the brain, which may improve patient selection for surgery, prognostication, and long-term monitoring.
• How Many Anxious Kids in Community Mental Health Would Be Eligible for an RCT? And Does It Matter? Insights from a Naturalistic Sample and a Non-Systematic Review
  March 28, 2026 by Anya C English
  Background: Decades of randomized controlled trials (RCTs) support cognitive behavioral therapy (CBT) for pediatric anxiety, but exclusion criteria may limit generalizability to routine settings. We examined common exclusion criteria in recent CBT RCTs for pediatric anxiety, trends in these criteria over time, and whether meeting RCT exclusion criteria affects outcomes in a naturalistic sample. Methods: We reviewed 81 RCTs from the past 25 years assessing CBT for pediatric anxiety or related…
• Circuit-based neuromodulation for obsessive-compulsive disorder: a systematic review, meta-analysis, and translational case study
  March 27, 2026 by Ruoyu Ma
  CONCLUSIONS: This systematic review, meta-analysis, and case study suggest that circuit-based neuromodulation-particularly targeting the fronto-limbic circuit-may offer the most consistent benefit for treatment-refractory OCD. Larger, longer-term, and circuit-informed trials are needed to optimize individualized neuromodulation strategies.
• Understanding the Relationship Between Avoidant/Restrictive Food Intake Disorder and Obsessive-Compulsive Symptoms: A Systematic Review
  March 14, 2026 by Michelangelo Di Luzio
  Background: It is well documented in the scientific literature that obsessive-compulsive disorder (OCD) and various eating disorders may present overlapping psychopathological traits. Exploring these aspects could help to identify underlying features that connect different diagnostic categories. However, evidence is lacking regarding certain less-studied eating disorders, such as avoidant/restrictive food intake disorder (ARFID). The aim of this review is to investigate the presence of…
• A systematic review of transcranial magnetic stimulation for generalized anxiety disorder, obsessive-compulsive disorder, and posttraumatic stress disorder
  March 11, 2026 by Shivani M Reddy
  CONCLUSIONS: TMS probably improves clinical response in OCD and may improve symptom severity in GAD, OCD, and PTSD. Further research should determine optimal brain targets and TMS treatment parameters and assess the durability of outcomes at longer term follow-up times, to better support clinical decision making and coverage determinations.
• Current state of the evidence on treatments for obsessive-compulsive disorder in children and adolescents: An umbrella review
  February 28, 2026 by Marina Serrano-Ortiz
  Obsessive-compulsive disorder (OCD) is a frequent condition in the pediatric population, with significant clinical impact and high comorbidity. This umbrella review aimed to synthesize evidence from systematic reviews and meta-analyses on the efficacy of interventions for OCD in individuals under 18 years of age. Searches were conducted in five electronic databases up to July 2025. A total of 28 systematic reviews and meta-analyses published between 2003 and 2025 were included, assessing the…
• Automated Joint Space Width Assessment in Patients Treated for Juvenile Osteochondritis Dissecans of the Distal Femur: A Cross-Sectional Study and Systematic Review of the Literature
  February 27, 2026 by Matthias Pallamar
  Background/Objectives: Juvenile osteochondritis dissecans (JOCD) of the knee is commonly treated using conservative or joint-preserving surgical techniques. While clinical outcomes are generally favorable, the risk of early cartilage degeneration remains unclear. Joint space width (JSW) on weight-bearing radiographs serves as an indirect marker of cartilage health. Artificial intelligence (AI)-based JSW assessment may enable sensitive and reproducible detection of early degenerative changes….
• Neuroimaging in lesioning therapy for obsessive-compulsive disorder: region-based and network analysis of preoperative outcome predictors and postoperative effects
  February 26, 2026 by Lyndon Boone
  CONCLUSION: Despite high methodological heterogeneity and small sample sizes in the primary literature, these findings underscore the potential of neuroimaging to inform patient selection and clarify mechanisms of OCD lesioning therapy. Network analyses may provide a framework for considering novel therapeutic targets. Future prospective research should verify the role of the anterior cingulate cortex in predicting treatment response, and further explore mechanistic changes in distributed brain…
• Do first-line treatments for OCD impact brain structure and function? A systematic review
  February 25, 2026 by Acácio Moreira-Neto
  No abstract
• Immersive virtual reality psychotherapy for children and adolescents-A systematic review and meta-analysis
  February 24, 2026 by Steffen Massanneck
  Although virtual reality has been used in psychotherapy since the 1990s, research and clinical practice have focused strongly on its application in exposure therapy. Over the last decade, the emergence of a new generation of virtual reality devices has led to a surge in virtual reality applications, which are also gaining traction in other areas of mental health care. The use of virtual reality in children and adolescent psychotherapy is especially interesting because it provides engaging and…

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